Pancreatic cancer: Long overdue for a new treatment approach

Despite advances in treatments for other cancers, mortality rates in pancreatic cancer have remained unchanged for more than 30 years. For all stages combined, 5-year relative survival is just 7%.1

Indoximod is making strides in metastatic pancreatic cancer research2

NewLink Genetics’ indoximod is a small-molecule indoleamine 2,3-dioxygenase (IDO) pathway inhibitor that has the potential to disrupt mechanisms by which tumors evade the immune system.3,4

 
Learn about the IDO pathway and IDO pathway inhibitors

 

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Learn more about the indoximod study in metastatic pancreatic cancer

 

References

1. American Cancer Society. Cancer facts and figures 2015. http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf. Accessed October 3, 2015. 2. National Institutes of Health. Study of IDO inhibitor in combination with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer. http://clinicaltrials.gov/ct2/show/record/NCT02077881. Accessed October 4, 2015. 3. Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol. 2013;34(3):137-143. 4. Baban B, Chandler PR, Sharma MD, et al. IDO activates regulatory T cells and blocks their conversion into Th17-like helper T cells. J Immunol. 2009;183(4):2475-2483.

Photo of Ronee Wagener

Ronee Wagener

Joined the team: 2007
Focus: Human Resources

I never in a million years would have thought I would be working for a company that conducts cancer research with such a noble cause.